Association of DRD2 and DRD3 polymorphisms with Parkinson's disease in a multiethnic consortium
โ Scribed by V. McGuire; S.K. Van Den Eeden; C.M. Tanner; F. Kamel; D.M. Umbach; K. Marder; R. Mayeux; B. Ritz; G.W. Ross; H. Petrovitch; B. Topol; R.A. Popat; S. Costello; A.D. Manthripragada; A. Southwick; R.M. Myers; L.M. Nelson
- Book ID
- 119304124
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 199 KB
- Volume
- 307
- Category
- Article
- ISSN
- 0022-510X
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Genes encoding proteins involved in dopaminergic transmission have been of special interest during the evaluation of candidate genes for Parkinson's disease (PD). The dopamine D2 receptor gene (DRD2) is located on chromosome 11 q22-q23, and several polymorphisms of the gene have been described. The
## Abstract Previous studies have demonstrated that the __TaqIA__ polymorphism of the D2 dopamine receptor gene (__DRD__2) is associated with response to dopaminergic and antidopaminergic treatment in Parkinson's disease (PD) and schizophrenia, respectively. We tested whether the __TaqIA__ genotype