Association of cyclin D1 polymorphism with increased susceptibility to oral squamous cell carcinoma
β Scribed by Sarah L. Holley; Christoph Matthias; Volker Jahnke; Anthony A. Fryer; Richard C. Strange; Paul R. Hoban
- Book ID
- 113832467
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 94 KB
- Volume
- 41
- Category
- Article
- ISSN
- 1368-8375
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## Abstract Overexpression of cyclin D1, a G1 cell cycle regulator, is often found in many different tumor types, including oral squamous cell carcinomas (SCC). Recent laboratory experiments have demonstrated that cyclin D1 levels can influence radiosensitivity in various cell lines. This study eva
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## Abstract Cyclin D1 is a wellβknown cell cycle regulator. Recently, its proβsurvival function has been revealed in several tumors. Because increasing expression of cyclin D1 is a common event in oral squamous cell carcinoma (OSCC) and has been correlated with cisplatin resistance, we investigated