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Association of CK19 mRNA detection of occult cancer cells in mediastinal lymph nodes in non-small cell lung carcinoma and high risk of early recurrence

✍ Scribed by Françoise Le Pimpec-Barthes; Claire Danel; Roger Lacave; Sylvie Ricci; Xavier Bry; Frédérique Lancelin; Cécile Leber; Bernard Milleron; Jocelyne Fleury-Feith; Marc Riquet; Jean-François Bernaudin


Book ID
116428375
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
291 KB
Volume
41
Category
Article
ISSN
0959-8049

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Real-time RT-PCR detection of CK19, CK7
✍ Pierre Saintigny; Séverine Coulon; Marianne Kambouchner; Sylvie Ricci; Emmanuel 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 French ⚖ 111 KB

## Abstract Metastatic lymph nodes (LNs) are the major prognostic factor in resected non small cell lung carcinoma (NSCLC). However, almost 50% of pN0 patients relapse, suggesting metastatic cells undetected by current staging procedures. A combination of markers [cytokeratins 19 and 7 (CK19, CK7)