Association of BDNF Val66Met polymorphism with both baseline HRQOL scores and improvement in HRQOL scores in Chinese major depressive patients treated with fluoxetine
✍ Scribed by Yan-Feng Zou; Yu Wang; Ping Liu; Xiao-Liang Feng; Bin-Yan Wang; Tong-Hua Zang; Xin Yu; Jing Wei; Zhong-Chun Liu; Ying Liu; Ming Tao; Hui-Chun Li; Ke-Qing Li; Jian Hu; Ming Li; Ke-Rang Zhang; Dong-Qing Ye; Xi-Ping Xu
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 125 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0885-6222
- DOI
- 10.1002/hup.1099
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✦ Synopsis
Abstract
Objective
To explore the association of brain‐derived neurotrophic‐factor (BDNF) Val66Met polymorphism with both baseline health related quality of life (HRQOL) scores and improvement in HRQOL scores in Chinese major depressive patients treated with fluoxetine.
Methods
Patients with major depressive disorder (MDD) took fluoxetine (20 mg/day) for 6 weeks. The HRQOL was measured with the Medical Outcomes Study Short Form‐36 (SF‐36) at baseline and at 6th week. Patients were genotyped for Val66Met polymorphism of BDNF gene.
Results
There was a significant association between social function (SF) and BDNF Val66Met polymorphism, and patients with Met/Met genotype had better SF (compared with Val/Val P = 0.004; compared with Val/Met P = 0.005). A significant association was found between improvement in SF and BDNF Val66Met polymorphism, and patients with Met/Met genotype had poorer improvement in SF (compared with Val/Val P = 0.010; compared with Val/Met P = 0.001). Similar association was found between improvement in mental component summary (MCS) and BDNF Val66Met polymorphism, and patients with Met/Met genotype had poorer improvement in MCS (compared with Val/Val P = 0.066; compared with Val/Met P = 0.006).
Conclusions
These results indicate that there may be association between BDNF Val66Met polymorphism and both baseline HRQOL (SF) scores and improvement in HRQOL (SF, MCS) scores in Chinese major depressive patients treated with fluoxetine. Copyright © 2010 John Wiley & Sons, Ltd.