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Association of a mutation in the ryanodine receptor 1 gene with equine malignant hyperthermia

✍ Scribed by Monica Aleman; Joyce Riehl; Brian M. Aldridge; Richard A. Lecouteur; Jeffrey L. Stott; Isaac N. Pessah


Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
548 KB
Volume
30
Category
Article
ISSN
0148-639X

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Malignant hyperthermia (MH) is a dominantly inherited pharmacogenetic condition that manifests as a life-threatening hypermetabolic reaction when a susceptible individual is exposed to common volatile anesthetics and depolarizing muscle relaxants. Although MH appears to be genetically heterogeneous,