Association of a 9.2-kilobase pvu ii class i major histocompatibility complex restriction fragment length polymorphism with ankylosing spondylitis
✍ Scribed by D. Olga McDaniel; Ronald T. Acton; Bruce O. Barger; William J. Koopman; John D. Reveille
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 822 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0004-3591
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✦ Synopsis
We analyzed DNA restriction fragment length polymorphism (RFLP) in 53 white ankylosing spondylitis (AS) patients and 92 healthy controls, utilizing a full-length HLA-B7 complementary DNA probe. A 9.2kilobase (kb) Pvu I1 fragment was found to be significantly increasexn frequency in B27 positive AS patients compared with the B27 positive control group (P = 0.00085, relative risk = 7.2). The presence of both B27 and the 9.2-kb RFLP in an individual conferred a relative risk for AS of 297, compared with a relative risk of 119 in those who had B27 alone. The 9.2-kb RFLP appears to be a marker for AS which, with HLA-B27, contributes further to susceptibility to the disease. Our