Association in Long-Evans hooded rats of red cell 2,3-diphosphoglycerate levels with hemoglobin types
✍ Scribed by G. Brewer; J. Gilman; N. Noble; V. Crews
- Publisher
- Springer
- Year
- 1978
- Tongue
- English
- Weight
- 705 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0006-2928
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✦ Synopsis
Two sublines of commercially available Long-Evans hooded rats have been developed by genetic selection. These sublines have widely differing levels of erythrocyte 2,3-diphosphoglycerate (DPG) due to different alleles at a single genetic locus. In the present work, it is shown that rats from the commercial population are also polymorphic at a hemoglobin locus, probably involving two alleles of the mfi-globin chain locus. Particular hemoglobin types have been found to be strongly associated with certain DPG types, not only in the high-DPG and low-DPG lines but also in the commercial population. Two explanations for this association are considered. One is a single-locus hypothesis, with hemoglobin allelic variation causing DPG variation, and the other is a two-locus hypothesis, with marked linkage disequilibrium.