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Association Between the Photodynamic Loss of Bcl-2 and the Sensitivity to Apoptosis Caused by Phthalocyanine Photodynamic Therapy

โœ Scribed by Jitsuo Usuda; Kashif Azizuddin; Song-mao Chiu; Nancy L. Oleinick


Book ID
111837072
Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
366 KB
Volume
78
Category
Article
ISSN
0031-8655

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Zn(II)-phthalocyanine (ZnPc) and its octapentyl (ZnOPPc) and octadecyl (ZnODPc) derivatives have been intravenously injected at a dose of 1.46 ixmol/kg into female Balb/c mice bearing an intramuscularly transplanted MS-2 fibrosarcoma. Pharmacokinetic studies show that in all cases the maximal concen