Association between the G870A polymorphism of Cyclin D1 gene and glioma risk
β Scribed by Zong, Hailiang; Cao, Lei; Ma, Chong; Zhao, Jianping; Ming, Xing; Shang, Ming; Xu, Hongsheng
- Book ID
- 121849719
- Publisher
- S. Karger AG
- Year
- 2014
- Tongue
- English
- Weight
- 250 KB
- Volume
- 35
- Category
- Article
- ISSN
- 1010-4283
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## Abstract __CCND1__ mRNA is alternatively spliced to produce 2 transcripts, and the splicing pattern may be modulated by a frequent __A__870__G__ singleβnucleotide polymorphism within the conserved splice donor site of exon 4. Several studies have suggested a significant association between the _
## Abstract ## Background. Nasopharyngeal cancer (NPC) is multifactorial, and the genetic background may be a crucial etiologic factor. Cyclin D1 (CCND1) is a key regulator of the cell cycle, and its altered activity is associated with the development of cancer. ## Methods. We analyzed the A870G