✦ LIBER ✦
Association between reactive arthritis and antecedent infection with shigella flexneri carrying a 2-md plasmid and encoding an hla–b27 mimetic epitope
✍ Scribed by H. Stieglitz; P. Lipsky
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 480 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0004-3591
No coin nor oath required. For personal study only.
✦ Synopsis
To determine whether Shigellaflexneri strains that cause enteric infection and are associated with reactive arthritis (ReA) carry a 2-Md plasmid, pHS-2, which encodes an HLA-B27 mimetic epitope.
Methods. Plasmid DNA from Shigella isolates was characterized by DNA-DNA hybridization, restriction endonuclease digestion, and sequencing.
Results. S jlexneri strains associated with ReA carried a 2-Md plasmid homologous to pHS-2.
Conclusion. The finding of pHS-2 in additional Shigella strains associated with ReA underscores its potential importance in the etiology of the disease.