Association Between Polymorphisms of the Dopamine Receptor D2 and Catechol-o-Methyl Transferase Genes and Cognitive Function
โ Scribed by Jennifer L. Bolton; Riccardo E. Marioni; Ian J. Deary; Sarah E. Harris; Marlene C. Stewart; Gordon D. Murray; F. Gerry R. Fowkes; Jackie F. Price
- Publisher
- Springer US
- Year
- 2010
- Tongue
- English
- Weight
- 210 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0001-8244
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We examined the allelic association between the dopamine D2 receptor (DRD2) gene and alcoholism in 100 biologically unrelated Japanese alcoholics and 93 unrelated controls. Genomic DNA was prepared from peripheral white blood cells using the phenol-chloroform method. A 310-bp region surrounding the
The human dopamine D 2 receptor gene (DRD 2 ) has received considerable attention for the past several years as a potential candidate that may affect susceptibility to alcoholism. The association studies that compared the frequencies of alleles of DRD 2 gene between alcoholics and control groups hav