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Association between frequent CpG island methylation and HER2 amplification in human breast cancers

✍ Scribed by Terada, K.; Okochi-Takada, E.; Akashi-Tanaka, S.; Miyamoto, K.; Taniyama, K.; Tsuda, H.; Asada, K.; Kaminishi, M.; Ushijima, T.


Book ID
124091785
Publisher
Oxford University Press
Year
2009
Tongue
English
Weight
372 KB
Volume
30
Category
Article
ISSN
0143-3334

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## Abstract Treatment success of breast cancer patients with trastuzumab alone or in combination depends not only on __HER2/NEU__ amplification but also on __PTEN__ and PI3K status and efficient cell death programs. In this pilot study, we found a significant association between loss of __beclin 1_