Association between expression of embryonic lethal abnormal vision-like protein HuR and cyclooxygenase-2 in oral squamous cell carcinoma

✍ Scribed by Jeong-Dan Cha; ShengJin Li; In-Ho Cha

• Book ID: 102847627
• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 746 KB
• Volume: 33
• Category: Article
• ISSN: 1043-3074
• DOI: 10.1002/hed.21507

✦ Synopsis

Abstract

Background

Increased cytoplasmic HuR expression has been noted in several cancer types, where it may contribute to the increased cyclooxygenase‐2 (COX‐2) expression observed during tumorigenesis and metastasis.

Methods

To assess the correlation between COX‐2 and HuR in oral squamous cell carcinoma (OSCC), the expression patterns of HuR and COX‐2 were assessed via immunohistochemistry analyses of 103 OSCC samples.

Results

Cytoplasmic HuR expression was significantly associated with COX‐2 expression (p < .025) and lymph node metastasis (p < .050) and distant metastasis (p < .025). In multivariate analysis, cytoplasmic HuR expression was identified as an independent prognostic parameter for reduced overall survival. The inhibition of HuR expression by siRNA or leptomycin B (LMB) caused a reduction in the inducibility of COX‐2 in oral cancer cells.

Conclusion

Our results indicate that the cytoplasmic expression of HuR is associated with COX‐2 expression in OSCCs and HuR can regulate COX‐2 expression in oral cancer cell lines. © 2010 Wiley Periodicals, Inc. Head Neck, 2011