Association between brain-derived neurotrophic factor gene and a severe form of bipolar disorder, but no interaction with the serotonin transporter gene
β Scribed by Ilona Vincze; Nader Perroud; Catherine Buresi; Patrick Baud; Frank Bellivier; Bruno Etain; Claire Fournier; Felicien Karege; Marie-Louise Matthey; Martin Preisig; Marion Leboyer; Alain Malafosse
- Book ID
- 110906489
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 134 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1398-5647
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## Abstract Recent studies have indicated that the brainβderived neurotrophic factor (__BDNF__) gene is involved in the etiology of bipolar disorder (BPD). Two familyβbased association studies showed that the Val allele of the functional polymorphism Val66Met in the __BDNF__ gene is associated with
## Abstract Several lines of evidence indicate an involvement of brain derived neurotrophic factor (BDNF) in body weight regulation and activity: heterozygous __Bdnf__ knockout mice (__Bdnf__^+/β^) are hyperphagic, obese, and hyperactive; furthermore, central infusion of BDNF leads to severe, doseβ