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Association between a 19 bp deletion polymorphism at the dopamine beta-hydroxylase (DBH) locus and migraine with aura

✍ Scribed by F. Fernandez; R.A. Lea; N.J. Colson; C. Bellis; S. Quinlan; L.R. Griffiths

Book ID: 119302108
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 124 KB
Volume: 251
Category: Article
ISSN: 0022-510X
DOI: 10.1016/j.jns.2006.09.013

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## Abstract The __DBH__ locus controls plasma dopamine β‐hydroxylase activity (pDβH). A 5′‐upstream single nucleotide polymorphism (SNP) at __DBH__ (−1021C → T) explains ∼45% of the variance in pDβH, and a non‐synonymous SNP in exon 11 (+ 1603C → T) an additional 2%. However, that regression result