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Association analysis of a regulatory promoter polymorphism of the PAX-6 gene with idiopathic generalized epilepsy

✍ Scribed by Thomas Sander; Yana Syagailo; Jerzy Samochowiec; Olga Okladnova; Klaus-Peter Lesch; Dieter Janz


Book ID
108461536
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
79 KB
Volume
36
Category
Article
ISSN
0920-1211

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The gene encoding the GABA B receptor (GABA B R1) maps close to the HLA-F locus on chromosome 6p21.3 in the same region to which a major susceptibility locus for common subtypes of idiopathic generalized epilepsy (IGE), designated as EJM1, has been localized. Moreover, animal models suggest that the