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Association analysis between polymorphisms in the myo-inositol monophosphatase 2 (IMPA2) gene and bipolar disorder

✍ Scribed by Paul J. Bloch; Andrew E. Weller; Glenn A. Doyle; Thomas N. Ferraro; Wade H. Berrettini; Rachel Hodge; Falk W. Lohoff

Book ID: 116842007
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 295 KB
Volume: 34
Category: Article
ISSN: 0278-5846
DOI: 10.1016/j.pnpbp.2010.08.015

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## Abstract Genetic linkage studies in bipolar disorder (BPD) suggest that a susceptibility locus exists on chromosome 18p11. The metallophosphoesterase (__MPPE1__) gene maps to this region. Dysregulation of protein phosphorylation and subsequent abnormal cellular signaling has been postulated to b