Assignment of the gene locus for the sixth component (C6) of complement in mice to chromosome 15

✍ Scribed by Jun-ichiro Hayakawa; Hiroko Nikaido; Tsutomu Koizumi

• Publisher: Springer-Verlag
• Year: 1985
• Tongue: English
• Weight: 390 KB
• Volume: 22
• Category: Article
• ISSN: 0093-7711
• DOI: 10.1007/bf00430312

✦ Synopsis

A structural locus (C-6) for the sixth component of complement in mice is assigned to chromosome 15. Three-point linkage analysis indicated that the order of loci is C-6, Gpt-1, Gdc-l, and that the map distances are 25.9+_4.9 between C-6 and Gpt-1, and 36.4 +_ 5.5 between C-6 and Gdc-1. Since Gdc-1 is more distal than Gpt-1, and C-6 is 26 cM away from Gpt-1, it is estimated that the C-6 is proximal to the centromere. In addition, a new C6 form found in AKR mice is described. We propose the designation C6B for it and C-.6 b for the allele encoding C6B.