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Assignment of structural β-galactosidase loci to human chromosomes 3 and 22

✍ Scribed by J. Wit; H. L. Hoeksema; D. Bootsma; A. Westerveld

Publisher: Springer
Year: 1979
Tongue: English
Weight: 665 KB
Volume: 51
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf00283392

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✦ Synopsis

Hybrid cell lines isolated after fusions between Chinese hamster E36 cells and normal human white blood cells were analyzed for human beta-galactosidase isoenzymes and for human chromosomes, especially 3, 12, and 22, the candidates for bearing a beta-galactosidase locus. Results of neuraminidase treatment of the cell lysates and immunological studies showed that in man two structural beta-galactosidase loci are present and can be assigned to chromosomes 3 and 22. No correlation was found between the expression of human beta-galactosidase and the presence of human chromosome 12.

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