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Assignment of peptidase S (PEPS) to chromosome 4 in man using somatic cell hybrids

✍ Scribed by T. B. Shows; J. A. Brown; R. L. Eddy; M. G. Byers; L. L. Haley; E. S. Cooper; A. P. Goggin

Publisher: Springer
Year: 1978
Tongue: English
Weight: 387 KB
Volume: 43
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf00293588

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✦ Synopsis

A starch gel electrophoretic procedure is described that resolves peptidase S (PEPS) as well as the peptidases A, B, and C in man-rodent, rodent-rodent, and primate-rodent interspecific somatic cell hybrids. The interspecific PEPS cell hybrid phenotype can be resolved into a pattern which suggests that PEPS is composed of five or six identical subunits. Results are presented supporting assignment of the PEPS locus to chromosome 4 in man using man-mouse and man-Chinese hamster somatic cell hybrids. Human genes coding for peptidases A, B, C, and D were assigned to chromosome 18, 12, 1, and 19, respectively, confirming previous assignments. These somatic cell genetic data demonstrate the independent genetic control of the several human peptidases.

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