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Assignment of casein kinase 2 alpha sequences to two different human chromosomes

✍ Scribed by Brigitte Boldyreff; Christine Klett; Elisabeth Göttert; Ad Geurts Kessel; Horst Hameister; Olaf-Georg Issinger

Book ID: 104664426
Publisher: Springer
Year: 1992
Tongue: English
Weight: 338 KB
Volume: 89
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf00207047

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✦ Synopsis

Human casein kinase 2 alpha gene (CK-2-alpha) sequences have been localized within the human genome by in situ hybridization and somatic cell hybrid analysis using a CK-2 alpha cDNA as a probe. By in situ hybridization, the CK-2 alpha cDNA could be assigned to two different loci, one on 11p15.1-ter and one on 20p13. The existence of two separate chromosomal loci suggests that CK-2 alpha is a member of a gene family. Only the locus on chromosome 11 was confirmed by somatic cell hybrid analysis. The analysis was based on the presence of a CK-2-alpha-specific 20-kb fragment. However, the CK-2 alpha cDNA hybridizes to several additional fragments in total human DNA.

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