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Assignment of a gene for human quinoid-dihydropteridine reductase (QDPR, EC 1.6.5.1) to chromosome 4

✍ Scribed by P. Kuhl; K. Olek; P. Wardenbach; K. -H. Grzeschik

Publisher: Springer
Year: 1979
Tongue: English
Weight: 401 KB
Volume: 53
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf00289450

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✦ Synopsis

An acrylamide gel electrophoretic procedure is described which allows the separation of human quinoid-dihydropteridine reductase (QDPR), EC 1.6.5.1) from the homologous enzyme expressed in established rodent cell lines. The human enzyme marker segregates exclusively with chromosome 4 in a series of well characterized man-mouse somatic cell hybrid clones from our clone bank. This observation supports the assignment of a structural gene for QDPR to human chromosome 4.

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