Assessment of whole body composition with dual energy X-ray absorptiometry in Duchenne muscular dystrophy: Correlation of lean body mass with muscle function

✍ Scribed by Genaro M.A. Palmieri; Tulio E. Bertorini; Judy W. Griffin; Masanori Igarashi; James G. Karas

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 276 KB
• Volume: 19
• Category: Article
• ISSN: 0148-639X
• DOI: 10.1002/(sici)1097-4598(199606)19:6<777::aid-mus15>3.0.co;2-i

✦ Synopsis

Ultras~nography~~" and magnetic resonance im-agingW 14 provide valuable regional information in myopathies, but they do not assess the total body composition and muscle mass. This has been accomplished by dual x-ray absorptiometry (DXA) 12,8 in normal subjects and in cystic fibrosis,'" acquired immunodeficiency syndrome," celiac disease,fi and in the differentiation of neurogenic from myogenic atrophies.'" In myopathies the fat body mass (FBM) is elevated and the lean body mass (LBM) is reduced." Measurements of LBM by DXA, which represents primarily skeletal muscle, correlate well with determinations of LBM by potassium-40 (R' = 0.996) . I 5

We have measured the body composition by DXA in 19 boys with Duchenne muscular dystrophy (DMD) and correlated the LBM with scores of functional activity and manual muscle testing.

Methods

Total body composition by DXA (DPX-L, Lunar Corporation, Madison, WI) was determined in 19 chil-From the Memphis Metabolic Bone Center,