Assessment of the repair and damage of dna induced by parent and reduced RSU-1069, a 2-nitroimidazole-aziridine

Reduced expression of the Rassf1a gene a

Reduced expression of the Rassf1a gene and its aberrant DNA methylation in pancreatic duct adenocarcinomas induced by N-nitrosobis(2-oxopropyl)amine in hamsters

✍ Kyoko Shimizu; Yumi Itsuzaki; Hiromasa Fujii; Kanya Honoki; Toshifumi Tsujiuchi 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 243 KB

## Abstract Alterations of the __Rassf1a__ gene were investigated in pancreatic duct adenocarcinomas (PDAs) induced by N‐nitrosobis(2‐oxopropyl)amine (BOP) in hamsters. Female Syrian golden hamsters received 70 mg/kg BOP, followed by repeated exposures to an augmentation pressure regimen consisting