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Assessment of the in vitro and in vivo properties of a 99mTc-labeled inhibitor of the multidrug resistant gene product P-glycoprotein

โœ Scribed by R Bergmann; P Brust; M Scheunemann; H.-J Pietzsch; S Seifert; F Roux; B Johannsen

Book ID
117688468
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
404 KB
Volume
27
Category
Article
ISSN
0969-8051

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Developmental expression of p-glycoprotein (multidrug resistance gene product) in the rat brain
โœ Matsuoka, Yasuji ;Okazaki, Mitsuhiro ;Kitamura, Yoshihisa ;Taniguchi, Takashi ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 430 KB ๐Ÿ‘ 2 views

P-Glycoprotein (PGP), a product of the multidrug resistance gene (mdr), acts as an adenosine triphosphate-dependent drug efflux system in cells. Initially, PGP was found in cancer cells, but it is now known that PGP is richly distributed in the adult brain. Passage to the central nervous system is l