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Assessment of the abuse potential of acetorphan, an enkephalinase inhibitor

✍ Scribed by Knisely, Janet S.; Beardsley, Patrick M.; Aceto, Mario D.; Balster, Robert L.; Harris, Louis S.

Book ID
122872093
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
825 KB
Volume
23
Category
Article
ISSN
0376-8716

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✍ S. J. Livingston; R. D. E. Sewell; K. F. Rooney; H. J. Smith πŸ“‚ Article πŸ“… 1988 πŸ› Springer 🌐 English βš– 477 KB

The effects of 60 min pretreatment with the enkephalinase inhibitor acetorphan were assessed on naloxone-precipitated (2.5 mg/kg IP) abstinence in chronically morphinized rats. In addition, the antinociceptive activity of the compound was investigated in mice. Intraperitoneal injection (50 mg/kg) in