Assessment of the ability of propoxur, methomyl, and aldicarb, three carbamate insecticides, to induce micronuclei in vitro in cultured Chinese hamster ovary cells and in vivo in BALB/c mice
✍ Scribed by L.Y. Wei; J.S. Chao; C.C. Hong
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 75 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0893-6692
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✦ Synopsis
Three carbamate insecticides (propoxur, methomyl, chemicals, the MN response depended on sample and aldicarb) were evaluated for their ability to in-time and the number of treatments, while for aldiduce micronuclei (MN) in vitro using cultured Chi-carb, the response depended also on the route of nese hamster ovary (CHO) cells, and in vivo in exposure. These positive results demonstrate that mouse bone marrow erythrocytes. In vitro, all three propoxur, methomyl, and aldicarb are capable of insecticides induced a significant increase in micro-inducing structural and/or numerical chromonucleated binucleate cells, which was generally somal aberrations in mammalian cells either in both dose and sample time dependent. The in vivo vitro or in vivo. Furthermore, based on the results studies involved treating male BALB/c mice by dif-obtained, an optimal in vivo MN protocol for carferent routes, either once or on 3 consecutive days, bamate insecticides is a single treatment followed followed by multiple or single sampling. Treatment by blood sampling at 24 and 48 hr after treatby intraperitoneal injection or oral gavage induced ment. Environ. Mol. Mutagen. 29:386 -393, a significant increase in micronucleated reticulo-1997