Assessment of regional lung function impairment in airway obstruction and pulmonary embolic dogs with combined noncontrast electrocardiogram-gated perfusion and gadolinium diethylenetriaminepentaacetic acid aerosol magnetic resonance images
✍ Scribed by Nobuhiko Ogasawara; Kazuyoshi Suga; Yasuhiko Kawakami; Tomio Yamashita; Mohammed Zaki; Naofumi Matsunaga
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 742 KB
- Volume
- 20
- Category
- Article
- ISSN
- 1053-1807
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✦ Synopsis
Abstract
Purpose
To define regional function impairment in airway obstruction (AO) and pulmonary embolic (PE) dogs with a combination study of noncontrast electrocardiogram (ECG)‐gated perfusion and gadolinium diethylenetriaminepentaacetic acid (Gd‐DTPA) aerosol magnetic resonance (MR) images.
Methods
After acquisition of multiphase fast‐spin‐echo (FSE) MR images during cardiac cycles in 14 AO dogs and 19 PE dogs, ECG‐gated perfusion‐weighted (PW) images were obtained by subtraction between two‐phase images of the minimum lung signal intensity (SI) during systole and maximum SI during diastole. Each dog subsequently inhaled Gd‐DTPA aerosol for 20 minutes, and subtracted Gd‐DTPA aerosol images were obtained from precontrast and maximally enhanced images. ECG‐gated PW images were compared with intravenous Gd‐DTPA‐enhanced pulmonary arterial perfusion phase (PAPP) images.
Results
ECG‐gated PW images were consistent with Gd‐DTPA‐enhanced PAPP images in all dogs, with significant correlations in the affected‐to‐unaffected lung perfusion ratios (P < 0.005). Gd‐DTPA aerosol images showed sufficient and uniform enhancement in the unaffected lungs. In all the AO areas, these combined images showed the matched perfusion and aerosol deposition defects. These images showed perfusion defects without aerosol deposition defects in the relatively small embolized areas, but showed the matched defects in the widely embolized areas probably due to hypoxic bronchial constriction.
Conclusion
The combination MR studies may be acceptable for noninvasively defining regionally impaired lung function in AO and PE. J. Magn. Reson. Imaging 2004;20:46–55. © 2004 Wiley‐Liss, Inc.