Assessment of Parent-of-Origin Effects in Linkage Analysis of Quantitative Traits
β Scribed by Robert L. Hanson; Sayuko Kobes; Robert S. Lindsay; William C. Knowler
- Book ID
- 117853576
- Publisher
- American Society of Human Genetics
- Year
- 2001
- Tongue
- English
- Weight
- 579 KB
- Volume
- 68
- Category
- Article
- ISSN
- 0002-9297
- DOI
- 10.1086/319508
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We present an overview of pedigree-based variance component linkage methods and discuss their extension to oligogenic inheritance. As an example, oligogenic linkage analyses were performed using the quantitative trait Q4 from the GAW10 simulated data set. A strategy involving sequential oligogenic a
In linkage analysis of recessive traits, parental relationship is important. For the case that it is unknown, the question is investigated as to whether estimating parental relationship and using the estimated relationship in linkage analysis is beneficial. Results show that estimating parental rela