Assessment of myocardial perfusion by dynamic O-15-labeled water PET imaging: Validation of a new fast factor analysis
✍ Scribed by Itaru Adachi; Oliver Gaemperli; Ines Valenta; Tiziano Schepis; Patrick T. Siegrist; Valerie Treyer; Cyrill Burger; Koichi Morita; Philipp A. Kaufmann
- Publisher
- Springer
- Year
- 2007
- Tongue
- English
- Weight
- 839 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1071-3581
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✦ Synopsis
Background:
Factor analysis (fa) is an established method for separating myocardium from blood pool by use of oxygen 15-labeled water and positron emission tomography for analyzing myocardial blood flow (mbf). conventional fa methods generating images from sinograms (sinofa) are time-consuming, whereas fa can be performed on the reconstructed images (reconfa) in a fraction of time. we validated the mbf values obtained by reconfa versus sinofa.
Methods and results:
In 23 volunteers (mean age, 26.6 +/- 3.4 years) mbf was calculated from sinofa and reconfa and blindly reanalyzed 1 month later by the same observer. intraobserver agreement and reconfa-versus-sinofa agreement were assessed according to bland and altman (ba). reproducibility proved excellent for global sinofa (r = 0.968; p < .001; ba limits, -0.617 to 0.676 ml x min(-1) x g(-1)) and slightly superior for reconfa (r = 0.979; p < .001; ba limits, -0.538 to 0.558 ml x min(-1) x g(-1)), with wider limits of agreement for segmental mbf from sinofa (r = 0.777; p < .001; ba limits, -1.676 to 1.656 ml x min(-1) x g(-1)) and reconfa (r = 0.844; p < .001; ba limits, -1.999 to 1.992 ml x min(-1) x g(-1)). in addition, sinofa and reconfa showed excellent correlation (r = 0.975, p < .001) and agreement (ba limits, -0.528 to 0.648 ml x min(-1) x g(-1)) for global and segmental values (r = 0.955; p < .001; ba limits, -1.371 to 1.491 ml x min(-1) x g(-1)).
Conclusions:
Use of reconfa allows rapid and reliable quantitative mbf assessment with o-15-labeled water.