Assessment of idiopathic rapid-eye-movement sleep behavior disorder by transcranial sonography, olfactory function test, and FP-CIT-SPECT
✍ Scribed by Marcus M. Unger; Jens C. Möller; Karin Stiasny-Kolster; Katharina Mankel; Daniela Berg; Uwe Walter; Helmut Hoeffken; Geert Mayer; Wolfgang H. Oertel
- Book ID
- 102502038
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 272 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0885-3185
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✦ Synopsis
Abstract
Idiopathic rapid‐eye‐movement (REM) sleep behavior disorder (iRBD) has been suggested to be a risk factor for subsequent development of neurodegenerative disorders, especially Parkinson's disease (PD) and other α‐synucleinopathies. At present, it is not possible to predict whether or not an iRBD patient will eventually develop PD. Here, we report 5 iRBD patients who underwent a test battery comprising a neurological examination (including UPDRS rating), mini mental state examination testing, transcranial sonography, olfactory function testing, and presynaptic dopamine transporter imaging with FP‐CIT‐SPECT. Our preliminary data show the diverse pattern of individual combinations of pathological findings when a multimodal assessment approach is applied in this patient group. Large‐size longitudinal studies in iRBD patients are required to evaluate the usefulness of diagnostic tests to identify the subgroup of iRBD patients that is prone to develop PD. © 2007 Movement Disorder Society