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Assessment of human nter and cter BRCA1 mutations using growth and localization assays in yeast

✍ Scribed by Gaël A. Millot; Adeline Berger; Vincent Lejour; Jean-Baptiste Boulé; Claude Bobo; Christophe Cullin; Judith Lopes; Dominique Stoppa-Lyonnet; Alain Nicolas

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
512 KB
Volume
32
Category
Article
ISSN
1059-7794

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Assessment of human nter and cter BRCA1
Assessment of human nter and cter BRCA1 mutations using growth and localization assays in yeast
✍ Gaël A. Millot; Adeline Berger; Vincent Lejour; Jean-Baptiste Boulé; Claude Bobo 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 512 KB

A large number of missense mutations have been identified within the tumor suppressor gene BRCA1. Most of them, called "variants of unknown significance" (VUS), cannot be classified as pathogenic or neutral by genetic methods, which complicates their cancer risk assessment. Functional assays have be