There are a wide variety of laboratory tests available to assess damage to and functional impairment of the kidneys, although the effectiveness of these tests varies greatly depending upon the site specificity of the damage and to a lesser extent upon the animal species involved. Several traditiona
Assessment of hepatic function and damage in animal species. A review of the current approach of the academic, governmental and industrial institutions represented by the Animal Clinical Chemistry Association
โ Scribed by D. D. Woodman
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 673 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0260-437X
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โฆ Synopsis
There are a wide variety of laboratory tests available to assess damage to and functional impairment of the liver, though the effectiveness of these tests varies greatly depending upon the type of damage and the animal species involved. Species differences in tissue localization, metabolism, specificity and sensitivity of parameters relating to the liver influence the choice of tests. Some tests can be applied usefully to most animal species while others may be highly specific in one species but show very low discriminatory potential in others. The tests available, and their use in veterinary and toxicological investigations have been reviewed in the light of current practice in the U.K.
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Species differences in metabolism, tissue localization, specificity and sensitivity for cardiac damage influence the choice of biochemical investigation used in the assessment of cardiotoxicity. The tests currently used in toxicological studies are broadly categorized herein as enzymes and other pro