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Assessment of HBV persistent infection in an adult population in Taiwan

✍ Scribed by Hong-Wen Peng; Tsung-Sheng Su; Shou-Hwa Han; Chi-Kuan Ho; Chao-Hung Ho; King-Nien Ching; Benjamin N. Chiang

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
506 KB
Volume
24
Category
Article
ISSN
0146-6615

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✦ Synopsis

In order to study the prevalence of hepatitis B virus (HBV) in the adult population of Taiwan, we screened for the presence of HBV DNA in 205 blood samples from adult (20-59-year-old) volunteers. According to the serological markers of HBV, samples were divided into three groups: group I (173 subjects) was negative for both HBsAg and HBeAg; group II (14 subjects) was positive for both HBsAg and HBeAg; and group III consisted of 18 subjects who were HBsAg-positive but HBeAg-negative. Plasma HBV DNA was not detected in group I, but it was found in 85.7% and 11.8% of samples in group II and group III, respectively. A free-form HBV DNA was found in 14.3% of the leukocyte samples in group II. Furthermore, an integrated form of HBV DNA was detected in the leukocytes of two cases of group I who remained healthy based on clinical data. HBV DNA was also detected in the spermatozoa and liver cells of one of the cases.

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