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Assessment of a superparamagnetic iron oxide (ami-25) as a brain contrast agent

โœ Scribed by Thomas A. Kent; Michael J. Quast; Barry J. Kaplan; Robert S. Lifsey; Howard M. Eisenberg

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
441 KB
Volume
13
Category
Article
ISSN
0740-3194

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โœฆ Synopsis

Abstract

We have applied a superparamagnetic iron oxide formulation (AMIโ€25, Advanced Magnetics, Inc., Cambridge, MA) to image the cerebral vasculature. Contrastโ€enhanced images of normal anesthetized rats demonstrated excellent gray/white matter differentiation, consistent with known differences in blood perfusion, and cerebrospinal fluid spaces were clearly seen. Alterations in normal perfusion patterns due to barbiturate anesthesia and ischemia were clearly visible. We propose the use of this agent as an adjunct to MRI for the imaging of conditions with perfusion abnormalities. ยฉ 1990 Academic Press, Inc.

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