Assessment of 99mTc-labelled gentamicin in renal functional imaging

✍ Scribed by Kutlan Özker; Irfan Urgancioǧlu

• Publisher: John Wiley and Sons
• Year: 1985
• Tongue: French
• Weight: 260 KB
• Volume: 22
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.2580220910

✦ Synopsis

An aminoglycoside a n t i b i o t i c , gentamicin is 99m l a b e l l e d with Tc by the stannous chloride reduction. Scintigraphic s t u d i e s and organ d i s t r i b u t i o n of t h i s agent i n experimental animals showed a s e l e c t i v e renal l o c a l i z a t i o n .

The r a d i o a c t i v i t y remained f o r a r e l a t i v e l y long period i n the kidneys suggesting some tubular reabsorption following f i l t r a t i o n a t the glomerular 99m -_ l e v e l . The concentration of Tc-gentamicin i n the kidneys as a function of t i m e has been studied by a gamma camera interfaced to a computer. Renal r a d i o a c t i v i t y clearance curves were generated from the regions of i n t e r e s t s on each kidney.