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Assessment and compensation of susceptibility artifacts in gradient echo MRI of hyperpolarized 3He gas

✍ Scribed by Jim M. Wild; Stan Fichele; Neil Woodhouse; Martyn N.J. Paley; Andrew Swift; Larry Kasuboski; Edwin J.R. van Beek

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
476 KB
Volume
50
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

The effects of macroscopic background field gradients upon 2D gradient echo images of inhaled ^3^He in the human lung were investigated at 1.5 T. Effective compensation of in‐slice signal loss in ^3^He gradient echo images was then demonstrated using a multiple acquisition interleaved single gradient echo sequence. This method restores signal dephasing through a combination of separate images acquired with different slice refocusing gradients. In vivo imaging of volunteers with the sequence shows substantial restoration of signal at the lung periphery and close to blood vessels. The technique presented may be useful when using ^3^He MRI for volumetric measurements of lung ventilation and in studies using ^3^He combined with intravenous contrast as a means of assessing lung ventilation/perfusion (V/Q). Magn Reson Med 50:417–422, 2003. © 2003 Wiley‐Liss, Inc.

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