Assessing the Site of Recurrence in Patients with Secondary Hyperparathyroidism by a Simplified Casanova Autograftectomy Test

Assessment of ifosfamide pharmacokinetic

Assessment of ifosfamide pharmacokinetics, toxicity, and relation to CYP3A4 activity as measured by the erythromycin breath test in patients with sarcoma

✍ Rashmi Chugh; Thomas Wagner; Kent A. Griffith; Jeremy M.G. Taylor; Dafydd G. Tho 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 190 KB

## Abstract ## BACKGROUND. Ifosfamide is a chemotherapeutic agent that requires cytochrome P450 3A (CYP3A) for bioactivation and metabolism. To the authors' knowledge, the correlation between dose, pharmacokinetics, CYP3A, and toxicity has not been fully evaluated. A randomized Phase II trial was