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Assessing the risk of skin damage due to femtosecond laser irradiation

✍ Scribed by Frank Fischer; Beate Volkmer; Stefan Puschmann; Rüdiger Greinert; Eckhard Breitbart; Jürgen Kiefer; Roger Wepf

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
271 KB
Volume
1
Category
Article
ISSN
1864-063X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

We irradiated freshly excised skin biopsies with four irradiation regimes usually taken for multiphoton imaging. If there is any skin damaging, it is mainly an effect similar to the damaging effects of UV‐irradiation. Using fluorescent antibodies against cyclobutane‐pyrimidin‐dimers (CPDs) in combination with immuno‐fluorescence image analysis we quantitatively compared fs‐irradiation effects with UV‐irradiation (solar simulator). Based on these results we are giving a risk assessment. The results show that multi photon imaging using the parameters described here is in the ballpark of damaging occurring from every day sun exposure. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

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