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Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test

✍ Scribed by John F. Cryan; Rita J. Valentino; Irwin Lucki


Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
396 KB
Volume
29
Category
Article
ISSN
0149-7634

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Intraaccumbens injections of catecholamines noradrenaline and dopamine, though not of serotonin, stimulated locomotion by rats in an open field, 10-15 min later. Similar effects were observed 5 min after microinjection of apomorphine whereas clonidine only attenuated locomotor activity. On the other