𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Assessing heterogeneity of treatment effect in a clinical trial with the proportional interactions model

✍ Scribed by Kovalchik, Stephanie A.; Varadhan, Ravi; Weiss, Carlos O.

Book ID
121841873
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
566 KB
Volume
32
Category
Article
ISSN
0277-6715

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

Assessing Treatment Effect Heterogeneity
Assessing Treatment Effect Heterogeneity in Clinical Trials with Blocked Binary Outcomes
✍ Jeffrey M. Albert; Gary L. Gadbury; Edward J. Mascha πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 176 KB πŸ‘ 2 views

This paper addresses treatment effect heterogeneity (also referred to, more compactly, as 'treatment heterogeneity') in the context of a controlled clinical trial with binary endpoints. Treatment heterogeneity, variation in the true (causal) individual treatment effects, is explored using the concep

Assessing treatment–time interaction in
Assessing treatment–time interaction in clinical trials with time to event data: a meta-analysis of hypertension trials
✍ F. Boutitie; F. Gueyffier; S. J. Pocock; J. P. Boissel πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 178 KB πŸ‘ 3 views

Exploration of the variation of treatment effect over time in randomized clinical trials with low event rates is limited by lack of power. A meta-analysis on individual patient data from such trials can partly solve the problem, but brings other computational difficulties. Using an example in hypert

Modelling Survival Data to Examine Lengt
Modelling Survival Data to Examine Length of Treatment Effectiveness in a Clinical Trial
✍ Prof. Donald J. Slymen πŸ“‚ Article πŸ“… 1988 πŸ› John Wiley and Sons 🌐 English βš– 592 KB

In some clinical trials where the experimental treatment is found to beeffective in increasing survival, an important question is how long should the patient remain under treatment. Although the trial may not be designed to specifically answer this question, comparisons of the hazard curves among th