✦ LIBER ✦

Assertion that risperidone is superior to haloperidol for treatment of behavioural and psychological symptoms of dementia

✍ Scribed by Graham A. Jackson

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 48 KB
Volume: 22
Category: Article
ISSN: 0885-6230
DOI: 10.1002/gps.1691

No coin nor oath required. For personal study only.

✦ Synopsis

Dear Editor

I feel I cannot let the assertion that risperidone is superior to haloperidol for treatment of behavioural and psychological symptoms of dementia (Suh et al., 2006) go unchallenged. This paper shows no such thing.

There is a very basic flaw, which means that all findings are invalid. It makes the assumption that doses of haloperidol and risperidone are equivalent, which is not the case. It compares patients on a mean dose of haloperidol 0.83 mg daily with a mean of 0.80 mg risperidone daily, and concludes that the risperidone was found to be more efficacious for various behaviour difficulties.

However, could not all this difference be accounted for by the different dose equivalents used?

The British National Formulary (BNF, 2006) gives equivalent doses of antipsychotics, taking 100 mg chlorpromazine as a baseline. The equivalent dose of risperidone is 0.5-1 mg, while that of haloperidol is

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