Assays for the identification and evaluation of histone acetyltransferase inhibitors
โ Scribed by G Wynne Aherne; Martin G Rowlands; Lindsay Stimson; Paul Workman
- Book ID
- 117702063
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 178 KB
- Volume
- 26
- Category
- Article
- ISSN
- 1046-2023
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๐ SIMILAR VOLUMES
A modified method for the assay of histone acetyltransferase is presented. Previously reported methods depended upon the determination of the incorporation of radioactivity from [Wlacetyl coenzyme A into trichloroacetic acid (TCA)-precipitable material. However, as shown in this paper, [14C]acetylat
The role of histone acetyltransferases (HATs) in the regulation of crucial cellular functions, e.g., gene transcription, differentiation, and proliferation, has recently been documented and there is increasing evidence that aberrant expression of these enzymes may have a role to play in the developm