Assay procedure for spectrophotometric determination of dextroamphetamine sulfate and amobarbital formulated into timed-release capsules
✍ Scribed by Fabrizio De Fabrizio
- Publisher
- John Wiley and Sons
- Year
- 1972
- Tongue
- English
- Weight
- 208 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
✦ Synopsis
An analytical method is presented for the quantitative spectrophotometric determination of a combination of dextroamphetamine sulfate and amobarbital blended in long-acting pellets. The powdered mixture is dissolved in 50% ethanol, and the solution is poured onto an alginic acid column which holds dextroamphetamine. Amobarbital, which passes through the column with the alcoholic washings, is collected in a 1Wml. volumetric flask. The assay technique offers a rapid and accurate determination of the two therapeutically active ingredients. Synthetic mixtures were analyzed by the proposed method, and recovery was 98-101 %.
Keyphrases 0 Amobarbital-dextroamphetamine sulfate timed-release formulations-GLC separation, UV spectrophotometric