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Assay of the antiangiogenic compound TNP-470, and one of its metabolites, AGM-1883, by reversed-phase high-performance liquid chromatography in plasma

✍ Scribed by William D. Figg; Herman J.C. Yeh; Alain Thibault; James M. Pluda; Fumio Itoh; Robert Yarchoan; Michael R. Cooper


Publisher
Elsevier Science
Year
1994
Weight
449 KB
Volume
652
Category
Article
ISSN
0378-4347

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## Abstract High performance liquid chromatography/mass spectrometry using a heat nebulizer atmospheric pressure chemical ionization interface was investigated as a sensitive and selective technique for the chromatographic separation and quantitation of the anti‐angiogenic drug TNP‐470 and its pola