Assay of terpin hydrate and codeine elixir by gas chromatography

✍ Scribed by Harold J. Wesselman

• Publisher: John Wiley and Sons
• Year: 1968
• Tongue: English
• Weight: 333 KB
• Volume: 57
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600570830

✦ Synopsis

The silicone fluids appear to have certain physical, chemical, and biological properties which would make them useful as nonaqueous solvents for the administration of medicinal agents.

Based upon data from accelerated thermal studies, it was found that the dimethyl silicone fluid was superior to corn oil in preventing the thermal degradation of menadione.

The photodegradation studies indicated that, although corn oil was somewhat superior t o the dimethyl silicone fluid in preventing the degradation of menadione, photodegradation was rapid in both vehicles. Since photodegradation can be controlled during normal storage by protective packaging, its practical significance is less than the relatively uncontrollable thermal storage conditions.

In consideration of these findings, it may be concluded that the dimethyl silicone fluid is superior t o corn oil as a vehicle for menadione.

REFERENCES

(1) Spiegel, A.