Drugs of abuse, Alcohol, Striatum, Nucleus accumbens Nitric oxide (NO), a labile free-radical gas, is known to be a n important messenger in several cell systems, including endothelial cells, macrophages, and neurons. In brain, the particular uniqueness of NO as a biological messenger has expanded c
Assay of neuronal nitric oxide synthase by HPLC determination of citrulline
โ Scribed by Mats Carlberg
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 275 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0165-0270
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๐ SIMILAR VOLUMES
A free radical, nitric oxide (NO), besides being a messenger molecule in the brain, becomes a neurotoxin if overproduced. We recently reported that methylmercury (MeHg) induces neuronal NO synthase (nNOS) in Purkinje cells. In the present study, we examined the distribution and the mechanism of nNOS
Citrulline is formed as a co-product in the biosynthesis of nitric oxide from barginine by the action of either constitutive or inducible nitric oxide synthase which is present in a variety of cells. We have previously shown that the oxygen atom incorporated into both nitric oxide and citrulline der