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Assay of caffeine and its metabolites in the rat blood plasma using HPLC as a method for determination of metabolic ratios

✍ Scribed by Ya. G. Novitskaya, A. A. Litvin, V. P. Zherdev…

Book ID
120894503
Publisher
Allerton Press Inc
Year
2013
Tongue
English
Weight
126 KB
Volume
68
Category
Article
ISSN
0027-1314

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## Abstract A simple HPLC method with ultraviolet detection has been developed and validated for the simultaneous determination of haplamine and its metabolites (__trans__/__cis__‐3,4‐dihydroxyhaplamine) in rat. A liquid–liquid extraction was used to extract the compounds from rat plasma. The analy