Aspirin-induced teratogenesis: A unique pattern of cell death and subsequent polydactyly in the rat
✍ Scribed by Klein, Kenneth L. ;Scott, William J. ;Wilson, James G.
- Publisher
- John Wiley and Sons
- Year
- 1981
- Tongue
- English
- Weight
- 569 KB
- Volume
- 216
- Category
- Article
- ISSN
- 0022-104X
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✦ Synopsis
Abstract
Offspring of pregnant rats treated with a high dose of aspirin on day 11 of gestation frequently had predominantly right‐sided polydactyly of the hindlimbs at term. Aspirin‐treated embryos removed on day 12 exhibited a unique pattern of preaxial mesodermal cell death in the hindlimb buds. In addition, these embryos had a delay of the normal episode of cell death in the preaxial apical ectodermal ridge and an absence of cell death in a zone of physiological necrosis in the preaxial mesoderm thought to be instrumental in controlling preaxial digit formation. The role of cell death in the pathogenesis of polydactyly is discussed.