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Aspirin-induced blockade of NF-κB activity restrains up-regulation of glial fibrillary acidic protein in human astroglial cells

✍ Scribed by Moon-Kyoung Bae; Su-Ryun Kim; Hak-Joong Lee; Hee-Jun Wee; Mi-Ae Yoo; Sae Ock Oh; Sun-Yong Baek; Bong-Seon Kim; Jae-Bong Kim; Sik-Yoon; Soo-Kyung Bae

Book ID: 113485857
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 367 KB
Volume: 1763
Category: Article
ISSN: 0167-4889
DOI: 10.1016/j.bbamcr.2006.01.005

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## Abstract Blood vessel injury results in limited oxygen tension and diffusion leading to hypoxia, increased anaerobic metabolism, and elevated production of acidic metabolites that cannot be easily removed due to the reduced blood flow. Therefore, an acidic extracellular pH occurs in the local mi